Publications
Latest Publications
Tumor-targeted Delivery of a STING Agonist Improves Cancer Immunotherapy.
Wu Y-T, Fang, Y, Wei, Q et al.. PNAS 2022 119(49) : E2214278119.
The cGAS–STING Pathway as a Therapeutic Target in Inflammatory Diseases.
Decout A, Katz J, Venkatraman S, Ablasser A. Nature Review Immunology. 2021 21: 548-569.
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.
Li T, Huang T, Du M, et al. Nature Reviews Immunology 2021 21: 548-569.
2022
Tumor-targeted Delivery of a STING Agonist Improves Cancer Immunotherapy.
Wu Y-T, Fang, Y, Wei, Q et al.. PNAS 2022 119(49) : E2214278119.
2021
The cGAS–STING Pathway as a Therapeutic Target in Inflammatory Diseases.
Decout A, Katz J, Venkatraman S, Ablasser A. Nature Review Immunology. 2021 21: 548-569.
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.
Li T, Huang T, Du M, et al. Nature Reviews Immunology 2021 21: 548-569.
2020
Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy.
Aval L, Pease J, Sharma R, Pinato D. J Clin Med. 2020 9(10): 3323.
Old Dogs, New Trick: Classic Cancer Therapies Activate cGAS.
Yum S, Li M, Chen Z. Cell Research 2020 30: 639-648.
Trial Watch: STING Agonists in Cancer Therapy.
Naour J, Zitvogel L, Galluzzi L, et al. Oncoimmunology 2020 9(1) 1777624.
2019
Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and Immunotherapy.
Yum S, Li M, Frankel A, Chen Z. Annu. Rev. Cancer Biol. 2019 3: 323–344.
cGAS in Action: Expanding Roles Inimmunity and Inflammation.
Ablasser A, Chen, Z. Science 2019 363(643): 8657.
Cyro-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Shang G, Zhang C, Chen Z, et al. Nature 2019 567: 389-393.
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Gui X, Yang H, Tuo L, et al. Nature 2019 567: 262-266.
Structural basis of STING binding with and phosphorylation by TBK1.
Zhang C, Shang G, Gui X, et al. Nature 2019 567: 394-398.
2017
cGAS is essential for cellular senescence.
Yang H, Wang H, Junyao, R, et al. PNAS 2017 114(23): E4612-E4620.
cGAS is essential for the antitumor effect of immune checkpoint blockade.
Wang H, Hu S, Xiang C, et al. PNAS 2017 114(7): 1637-1642.
2015
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Gao D, Tuo, L, et al. PNAS 2015 112(42):E5699-E5705.
2013
Revving up cGAS.
Cain C. Science-Business eXchange 6(40): 1117.
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses.
Gao D, Jiaxi W, You-Tong W, et al. Science, 2013 341(6148): 903-906.
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Wu J, Lijun S, Xiang C, et al. Science 2013 339(6121): 826-830.
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Sun L, Wu J, Fenghe D, et al. Science, 2013 339(6121): 786-791.